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Inactivation of the retinoblastoma gene in a human lung carcinoma cell line detected by single-strand conformation polymorphism analysis of the polymerase chain reaction product of cDNA


Book ID
122074084
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
159 KB
Volume
7
Category
Article
ISSN
0169-5002

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Analysis of single-stranded conformation polymorphisms in polymerase chain reaction (PCR) products (PCR-SSCP) is a sensitive method for detecting point mutations in genomic DNA. To investigate its utility in examining the androgen receptor gene, we analyzed data on a patient with the testicular femi