Inactivation of the hMSH3 mismatch repair gene in bladder cancer
โ Scribed by Toshifumi Kawakami; Hiroaki Shiina; Mikio Igawa; Masao Deguchi; Koichi Nakajima; Tatsuya Ogishima; Takashi Tokizane; Shinji Urakami; Hideki Enokida; Kazukiyo Miura; Nobuhisa Ishii; Christopher J. Kane; Peter R. Carroll; Rajvir Dahiya
- Book ID
- 116289460
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 782 KB
- Volume
- 325
- Category
- Article
- ISSN
- 0006-291X
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## Background: Several convincing studies have shown that the hmsh2 gene plays major roles in mismatch repair by recognizing mismatched bases and preventing mutations during dna replication. loss of this function may result in the accumulation of dna replication errors or even the mutator phenotype