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Inactivation of presynaptic 5-HT autoreceptors by lithium in rat hippocampus

✍ Scribed by Hide, Izumi; Yamawaki, Shigeto

Book ID
123187170
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
191 KB
Volume
107
Category
Article
ISSN
0304-3940

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Human cerebral cortical synaptosomes were used to determine the 5-hydroxytryptamine (5-HT) receptor subtype to which the inhibitory presynaptic 5-HT autoreceptor belongs. The synaptosomes preincubated with [3H~5-HT were superfused and tritium overflow was stimulated by high K +. The K +-evoked triti