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Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1Bbinding sites

✍ Scribed by G. Engel; M. Göthert; D. Hoyer; E. Schlicker; K. Hillenbrand

Book ID
112379549
Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
783 KB
Volume
332
Category
Article
ISSN
0028-1298

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Human cerebral cortical synaptosomes were used to determine the 5-hydroxytryptamine (5-HT) receptor subtype to which the inhibitory presynaptic 5-HT autoreceptor belongs. The synaptosomes preincubated with [3H~5-HT were superfused and tritium overflow was stimulated by high K +. The K +-evoked triti