The effects of 2-(4-(4-(2-pyrimidinyl)-l-piperazinyl)-butyl)-1,2-benzoisothiazol-3(2H)one-1,1-dioxide hydrochloride (isapirone, TVX Q 7821), a putative 5-HT1 receptor antagonist, has been studied on various models of 5-HT receptor sub-type function. In mice TVX Q 7821 produced a dose-dependent inhib
The effects of manipulation of presynaptic 5-HT nerve terminals on postsynaptic 5-HT1and 5-HT2binding sites of the rat brain
β Scribed by H. Hall; Ilse Wedel
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 739 KB
- Volume
- 64
- Category
- Article
- ISSN
- 1435-1463
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In the present study, the hypothesis that somatodendritic availability of 5-hydroxytryptamine (5-HT) could be regulated independently of the firing activity of dorsal raphe 5-HT neurons was tested. The 5-HT pathway was electrically stimulated at the level of the ventromedial tegmentum and the ensuin