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In vivoEfficacy of Neocarzinostatin Coupled with Fab Human/Mouse Chimeric Monoclonal Antibody A7 against Human Colorectal Cancer

โœ Scribed by Yamaguchi, Toshiharu ;Tsurumi, Hiroshi ;Kotani, Tatsuya ;Yamaoka, Nobuki ;Otsuji, Eigo ;Kitamura, Kazuya ;Takahashi, Toshio


Book ID
108580789
Publisher
Wiley (Blackwell Publishing)
Year
1994
Tongue
English
Weight
293 KB
Volume
85
Category
Article
ISSN
0910-5050

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Antitumor effect of neocarzinostatin con
โœ Eigo Otsuji; Toshiharu Yamaguchi; Yoshihiro Yata; Hiroshi Nishi; Kazuma Okamoto; ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 495 KB

The anticancer agent neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of the monoclonal antibody A7 to form the conjugate chA7Fab-NCS. The antitumor effect of chA7Fab-NCS was tested by measuring the inhibition of 3H-thymidine incorporation into human pancreatic carci