In vivo treatment with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces organ-specific alterations in in vitro repair of DNA pyridyloxobutylation
β Scribed by Pamela J. Brown; Thomas E. Massey
- Book ID
- 113809268
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 527 KB
- Volume
- 663
- Category
- Article
- ISSN
- 0027-5107
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## Abstract Urinary metabolites of the tobaccoβspecific nitrosamine 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di
## Abstract ## BACKGROUND In the United States, Blacks who smoke cigarettes have a higher mean blood concentration of the nicotine metabolite cotinine than White smokers. It has not been determined whether there are racial differences in the exposure to the cigarette smoke carcinogen 4β(methylnitr