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In vivo stabilization of nuclear retinoid X receptor α in the presence of peroxisome proliferator-activated receptor α

✍ Scribed by Naoki Tanaka; Kazuhiko Hora; Hideki Makishima; Yuji Kamijo; Kendo Kiyosawa; Frank J. Gonzalez; Toshifumi Aoyama


Book ID
117105384
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
233 KB
Volume
543
Category
Article
ISSN
0014-5793

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## Abstract The peroxisome proliferator‐activated receptor‐α (PPAR‐α) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR‐α agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE