✦ LIBER ✦

In vivo multiple-mouse imaging at 1.5 T

✍ Scribed by S. Xu; T.P.F. Gade; C. Matei; K. Zakian; A.A. Alfieri; X. Hu; E.C. Holland; S. Soghomonian; J. Tjuvajev; D. Ballon; J.A. Koutcher

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 1006 KB
Volume: 49
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.10397

No coin nor oath required. For personal study only.

✦ Synopsis

A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 microm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner.

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