In vivo monosomy 3 detection of posterior uveal melanoma: 3-year follow-up
β Scribed by Edoardo Midena; Laura Bonaldi; Raffaele Parrozzani; Pietro P. Radin; Barbara Boccassini; Stela Vujosevic
- Book ID
- 106097796
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 120 KB
- Volume
- 246
- Category
- Article
- ISSN
- 0065-6100
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## Abstract Gains and losses of chromosomes 1, 3, 6 and 8 are nonrandom chromosomal aberrations in uveal melanoma. Monosomy 3 is the most frequent abnormality and is associated with poor prognosis. To identify regions of allelic loss on the short arm of chromosome 1 and to investigate if these alte
Posterior uveal melanomas have nonrandom alterations affecting chromosomes 3, 6, and 8. Loss of chromosome 3 in uveal melanoma has been shown to act as a predictor of disease-free and overall survival. To confirm the significance of chromosome 3 loss and to extend the observations to include those o