## Abstract The oxygen dependencies of the 19F NMR spin‐lattice relaxation rates (__R__~__1__~ = 1/__T__~1~) of a perfluorocarbon emulsion sequestered in a murine tumor model has been used to evaluate nicotinamide, a radiosensitizer believed to act through enhanced tissue oxygenation. Fluorine‐19 N
In vivo mapping of tumor oxygen consumption using 19F MRI relaxometry
✍ Scribed by Caroline Diepart; Julie Magat; Bénédicte F. Jordan; Bernard Gallez
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 277 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0952-3480
- DOI
- 10.1002/nbm.1604
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Noninvasive methods to image the trafficking of phenotypically defined immune cells are paramount as we attempt to understand adaptive immunity. A ^19^F MRI‐based methodology for tracking and quantifying cells of a defined phenotype is presented. These methods were applied to a murine i
## Abstract ## Purpose To compare T1‐ or T2‐weighted magnetic resonance imaging (MRI) and ultrasonography (US) as tools for in vivo mapping of different tissue components in spontaneous tumors of transgenic mice. ## Materials and Methods Human‐like mammary adenocarcinomas from FVB/neuT transgeni
## Abstract A ^19^F magnetic resonance spectroscopy (MRS) approach to measuring hypoxia in experimental tumors in rats at a field strength of 2.35 T has been investigated in a combined study of __in situ__ and excised tumors. The detection of tumor hypoxia is based on the hypoxia marker approach wh
## Abstract Effective cancer chemotherapy depends on the delivery of therapeutic drugs to cancer cells at cytotoxic concentrations. However, physiologic barriers, such as variable vessel permeability, high interstitial fluid pressure, and heterogeneous perfusion, make it difficult to achieve that g
## Abstract A novel technique is presented to measure __in vivo__ simulataneously oxygen tension and temperature using ^19^F NMR spectroscopy of perfluorocarbon. This work examines the variation with oxygen tension (pO~2~) and temperature of the individual spin lattice relaxation rates (__R__~1~) o