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Development of an in vivo19F magnetic resonance method for measuring oxygen deficency in tumors

✍ Scribed by J. A. Raleigh; A. J. Franko; D. A. Kelly; L. A. Trimble; P. S. Allen

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
977 KB
Volume
22
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A ^19^F magnetic resonance spectroscopy (MRS) approach to measuring hypoxia in experimental tumors in rats at a field strength of 2.35 T has been investigated in a combined study of in situ and excised tumors. The detection of tumor hypoxia is based on the hypoxia marker approach which depends on the selective, covalent binding of a fluorinated 2‐nitromidazole to hypoxic cells. The ^19^F MRS measurement of in vivo hypoxia marker binding was made at a fixed postinjection time when unbound, circulating marker molecule concentrations had dropped below detectable levels. A correlation between ^19^F MRS and scintillation counting measures of tumor‐bound, tritium‐labeled hypoxia marker was observed. There was no correlation between integrated ^19^F MRS hypoxia marker signals and the in vivo ^31^P MRS parameters of hypoxia which have been developed to measure normal tissue ischemia. Radiolabeling studies and previous immunohistochemical studies with the fluorinated hypoxia marker support the conclusion that the ^19^F MRS approach has promise as a physically noninvasive guide to the use of hypoxia‐dependent therapies at clinically usable MRS field strengths. © 1991 Academic Press, Inc.

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