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In vivo hydroxyl radical generation in the striatum following systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

✍ Scribed by Bobby Thomas; Dhanasekharan Muralikrishnan; Kochupurackal P. Mohanakumar

Book ID: 114005499
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 117 KB
Volume: 852
Category: Article
ISSN: 0006-8993
DOI: 10.1016/s0006-8993(99)02202-7

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP