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In vivo evidence that human adrenal glands possess 11β-hydroxysteroid dehydrogenase activity

✍ Scribed by Cinzia Tortorella; Francesco Aragona; Gastone G. Nussdorfer

Book ID
117176592
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
358 KB
Volume
65
Category
Article
ISSN
0024-3205

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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit