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Cellular localization of 11β-hydroxysteroid dehydrogenase 2 gene expression in the ovine adrenal gland

✍ Scribed by K. Yang; S.G. Matthews

Book ID
116122657
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
643 KB
Volume
111
Category
Article
ISSN
0303-7207

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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit