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Expression of 11β-hydroxysteroid dehydrogenase type 2 (11βHSD-2) in the developing human adrenal gland and human adrenal cortical carcinoma and adenoma

✍ Scribed by Catherine L Coulter; Robin E Smith; Michael Stowasser; Hironobu Sasano; Zygmunt S Krozowski; Richard D Gordon


Book ID
117464210
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
707 KB
Volume
154
Category
Article
ISSN
0303-7207

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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit