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In Vivo Evaluation of Thiolated Chitosan Tablets for Oral Insulin Delivery

✍ Scribed by Millotti, Gioconda; Laffleur, Flavia; Perera, Glen; Vigl, Claudia; Pickl, Karin; Sinner, Frank; Bernkop-Schnürch, Andreas

Book ID
127231123
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
350 KB
Volume
103
Category
Article
ISSN
0022-3549

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In vivo evaluation of a nasal insulin de
In vivo evaluation of a nasal insulin delivery system based on thiolated chitosan
✍ Alexander H. Krauland; Verena M. Leitner; Vjera Grabovac; Andreas Bernkop-Schnür 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB

The aim of this study was the preparation and in vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. 2-Iminothiolane was covalently attached to chitosan. The resulting conjugate (chitosan-TBA) exhibited 304.9 +/- 63.5 micromol thiol groups per gram polymer. Microparticles