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In vivo evaluation of [123I]MNI-420: A novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain

✍ Scribed by Tavares, Adriana Alexandre dos Santos; Batis, Jeffery; Barret, Olivier; Alagille, David; Vala, Christine; Kudej, Greg; Koren, Andrei; Cosgrove, Kelly P.; Nice, Katie; Kordower, Jeffrey H.; Seibyl, John; Tamagnan, Gilles D.


Book ID
123229004
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
548 KB
Volume
40
Category
Article
ISSN
0969-8051

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## Abstract Iodobenzamide (IMB) labeled with either [^11^C] or [^125^I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D~2~ dopamine receptors. Mouse biodistribution studies with both [^11^C]IMB and [^125^I]IMB showed a similar brain