✦ LIBER ✦

In vivo degradation of silicones

✍ Scribed by Leoncio Garrido; Bettina Pfleiderer; Mikhail Papisov; Jerome L. Ackerman

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 473 KB
Volume: 29
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910290620

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

^29^Si nuclear magnetic resonance (NMR) spectroscopy is applied to study the degradation of polysiloxanes (silicones) in vivo. Our results with animal models show that silicone migrates from the implant to the liver (^29^Si resonance at −20 ppm) and new silicon containing compounds form after the silicones are introduced into the rats. The new ^29^Si resonances in the chemical shift range of −40 to −85 ppm are related to hydrolyzed silicone, those at −90 to −115 ppm are indicative of the presence of silica (SiO~2~), and the peaks observed at −120 to −150 are related to high coordinated silicon complexes. These resonances are not present in the ^29^Si spectra of the silicones before implantation. Our findings demonstrate that silicones are not metabolically inert.

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