✦ LIBER ✦

In vivo biocompatibility of an aliphatic crosslinked polyurethane in rabbit

✍ Scribed by Jayabalan, M. ;Shunmuga Kumar, N. ;Rathinam, K. ;Kumari, T. V.

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 661 KB
Volume: 25
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820251203

No coin nor oath required. For personal study only.

✦ Synopsis

A cage implantation technique has been a d o p t e d i n a rabbit animal model t o investigate the biocompatibility of a n aliphatic crosslinked polyurethane based on hexamethylene diisocyanate (HDI). In this study, four cages are represented; the cage containing t h e candidate polyu r e t h a n e material, biomedical grade polyurethane (Tecoflex), the commercial grade polyvinylchloride (PVC), and an empty cage which were implanted sub-cutaneously in rabbits. Exudates were aspirated from these cages at 4, 7, 14, and 21 days postimplantation. Exudates were analyzed for variations in proteins, cell counts, and extracellular enzymes. Results with the four types of cage implants showed that the candidate polyurethane caused an inflammatory response comparable to that caused by medical-grade Tecof lex and the empty cage control.

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