## Abstract The transformation of cultivated hamster brain cells by polyoma virus is reported. The transformed cell line contained polyoma virusβspecific nuclear, surface and transplantation antigens. Subcutaneous and intracranial inoculations revealed high tumorigenicity of the cells. Brainβspecif
β¦ LIBER β¦
In Vitro Transformation of Normal Cells by Polyoma Virus
β Scribed by SACHS, LEO; MEDINA, DAN
- Book ID
- 109613980
- Publisher
- Nature Publishing Group
- Year
- 1961
- Tongue
- English
- Weight
- 397 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/189457a0
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## Abstract Abortive transformation of layer cultures of BHK 21 cells by polyoma virus has been studied using serumβdepleted medium. High doses of partially purified infectious virus, in the absence of serum, stimulate the majority of the cells to synthesize DNA while empty capsids do not. The onse