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In vitro studies on the immunosuppressive effect of 2′,2′-difluorodeoxycytidine (dFdC) and its metabolite 2′,2′-difluorodeoxyuridine (dFdU)

✍ Scribed by Martin Tiefenthaler; Florian Hohla; Eveline Irschick; Elisabeth Strasser-Wozak; Nicole Bacher; Oliver Mühlmann; Wolfgang Wein; Günther Konwalinka

Book ID
117850930
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
115 KB
Volume
207
Category
Article
ISSN
0171-2985

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Effect of hyperthermia on the cytotoxici
Effect of hyperthermia on the cytotoxicity of 2′,2′-difluorodeoxycytidine (gemcitabine) in cultured SW1573 cells
✍ J. Haveman; R. C. Rietbroek; A. Geerdink; J. van Rijn; P. J. M. Barker 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 452 KB

Difluorodeoxycitidine (dFdCyd. gemcitabine) was tested for cytotoxicity in cultured human lung-cancer cells SW I573 in combination with I hr hyperthermia at 43'C. The results show that the timing is extremely important. Simultaneous application led to decreased cytotoxicity, whereas an interval of 2