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Effect of its deaminated metabolite, 2′,2′-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells

✍ Scribed by L.S. Hodge; M.E. Taub; T.S. Tracy

Book ID
113489452
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
495 KB
Volume
81
Category
Article
ISSN
0006-2952

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Effect of hyperthermia on the cytotoxicity of 2′,2′-difluorodeoxycytidine (gemcitabine) in cultured SW1573 cells
✍ J. Haveman; R. C. Rietbroek; A. Geerdink; J. van Rijn; P. J. M. Barker 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 452 KB

Difluorodeoxycitidine (dFdCyd. gemcitabine) was tested for cytotoxicity in cultured human lung-cancer cells SW I573 in combination with I hr hyperthermia at 43'C. The results show that the timing is extremely important. Simultaneous application led to decreased cytotoxicity, whereas an interval of 2