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In vitro mutagenicity of water contaminants in complex mixtures

✍ Scribed by M. M. Varma; F. R. Ampy; K. Verma; W. W. Talbot

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 409 KB
Volume: 8
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550080404

No coin nor oath required. For personal study only.

✦ Synopsis

Trihalomethanes, Carbon tetrachloride and trichloroethylene were tested in single, binary and multi-complex mixtures using standard tester strains TA1535, TA1537, TA98 and TAlOO of Salmonella fyphimurium with and without addition of an in vitro metabolizing fraction S-9. Chloroform (CHC13) was found to be mutagenic in all strains without S-9 activation. However, when tested with Bromoform (15%), which was nonmutagenic singly, the combined effect of the mixture was nonmutagenic. CC14 was a direct mutagen (without S-9) in all strains except TA 1535. When combined with 85% CHC13, only strains TA1535 and TA1537 were mutagenic. When tested with mammalian activation (S-9), CCI, was mutagenic in all strains. However, when tested with CHCl3 (CHC13 and CC, -85 : 15), the mutagenic capability was lost.

With or without S-9 Activation multi-complex mixture of CHCI,, CCl, and TCE (85 : 8 : 7) was mutagenic for a narrow range of doses in all strains.

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