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In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes

✍ Scribed by Crowell, S.R.; Hanson-Drury, S.; Williams, D.E.; Corley, R.A.

Book ID: 122900168
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 979 KB
Volume: 228
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2014.04.004

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino