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Metabolism of Phenanthrene, Benz[ a ]anthracene, Benzo[ a ]pyrene, Chrysene and Benzo[ c ]phenanthrene by Eight cDNA-expressed Human and Rat Cytochromes P450

✍ Scribed by Jacob, Jürgen; Doehmer, Johannes; Grimmer, Gernot; Soballa, Volker; Raab, Gottfried; Seidel, Albrecht; Greim, Helmut

Book ID
126840904
Publisher
Taylor and Francis Group
Year
1996
Tongue
English
Weight
484 KB
Volume
10
Category
Article
ISSN
1040-6638

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✍ Magang Shou; Kenneth R. Korzekwa; Charles L Crespi; Frank J. Gonzalez; Harry V. 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 881 KB

## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino