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In vitro effects of 4-hydroperoxycyclophosphamide on concanavalin A-induced human suppressor T cells

โœ Scribed by Abraham Klajman; Ilana Drucker; Yosef Manor; Shlomo Ben-Efraim

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
453 KB
Volume
18
Category
Article
ISSN
0340-7004

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โœฆ Synopsis

Treatment in vitro of human peripheral blood lymphocytes (PBL) with ConA induced the generation of suppressor cells which inhibited T cell blastogenic response to ConA and of allogeneic response in the mixed lymphocyte reaction (MLR). Treatment of PBL with 4-hydroperoxycyclophosphamide (4-HPCy) before incubation with ConA markedly decreased the generation of suppressor cells by ConA. The effect of 4-HPCy on generation of suppressor cells was more pronounced in the test of ConA stimulation than in the MLR. Treatment with 4-HPCy had no effect on suppressor cells already induced as shown by incubation of PBL with 4-HPCy after incubation with ConA.

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In vitro selective effect of melphalan o
In vitro selective effect of melphalan on human T-cell populations
โœ Shlomo Ben-Efraim; Luise Komlos; Jaffa Notmann; Jacob Hart; Isaac Halbrecht ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 428 KB

In vitro treatment with 2 ~tg/2 x 106 cells melphalan (L-PAM: L-phenylalanine mustard) significantly decreased the total number of T lymphocytes from peripheral blood (PBL) of healthy human donors and of the OKT 4 population (precursor suppressor~helper~inducer) T cells as defined by monoclonal anti