Effect of melphalan in vitro on induction of murine suppressor T cells by ConA
β Scribed by Rachel Ophir; Shlomo Ben-Efraim
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 510 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0340-7004
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π SIMILAR VOLUMES
In vitro treatment with 2 ~tg/2 x 106 cells melphalan (L-PAM: L-phenylalanine mustard) significantly decreased the total number of T lymphocytes from peripheral blood (PBL) of healthy human donors and of the OKT 4 population (precursor suppressor~helper~inducer) T cells as defined by monoclonal anti
Treatment in vitro of human peripheral blood lymphocytes (PBL) with ConA induced the generation of suppressor cells which inhibited T cell blastogenic response to ConA and of allogeneic response in the mixed lymphocyte reaction (MLR). Treatment of PBL with 4-hydroperoxycyclophosphamide (4-HPCy) befo