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In vitro digestion and fermentation of 5-formyl-aminosailcylate-inulin: A potential prodrug of 5-aminosalicylic acid

✍ Scribed by Hartzell, Annette L.; Maldonado-Gómez, María X.; Yang, Junyi; Hutkins, Robert W.; Rose, Devin J.

Book ID
122473941
Publisher
Elsevier
Year
2013
Tongue
English
Weight
947 KB
Volume
2
Category
Article
ISSN
2212-6198

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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speci®c prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti