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In vitro demonstration of tumor-specific antigens in spontaneous mammary tumors of mice

✍ Scribed by G. H. Heppner; G. Pierce

Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
447 KB
Volume
4
Category
Article
ISSN
0020-7136

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✦ Synopsis

The colony-inhibition test has been iised to demonstrate cellular imrriirnity against spontaneous murine mammary tumors, both in autochthonous, manimury tumor virus (MTV)-carrying BALBIcfC3N arid in ininiutiized, MTV-fret, BALBIc mice. Immunity could be demonstrated in nearly all cases against a niamniary tumor with lymph-node cells from mice which had experienced that tumor.

One of eight tumors tested with lymph-node cells from BALBIcfC3H mice which hut1 spontaneously developed mammary tumors showed evidence of ininiunological cross-reactivity, while seven of thirteen tumors did so wheti tested with ininiiinc~ cell.s from MTV-free BALBIc mice. The data, therryore, indicate the presence of at least two types of tumor-specific antigen(s) in niouse nianimary tumors -a coninion one and an antigen specific for each tzeoplasni.

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