S-(trans-l,2-Dichlorovinyl)-~-cysteine (DCVC) exposure causes acute renal tubular cytotoxicity. To further characterize the effects of DCVC, a chronic study was undertaken. Male Swiss-Webster mice received DCVC dissolved in their drinking water at 0.01, 0.05 and 0.1 mg ml-'. At 4, 8, 21 and 37 weeks
In vitro and in vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine
โ Scribed by Grushenka H.I. Wolfgang; A. Jay Gandolfi; James L. Stevens; Klaus Brendel
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 673 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0300-483X
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Precision-cut, rabbit renal slices were used to examine the effects of three novel antioxidants (U-74006, U-74500, and U-78517) on 5-(1,2-dichloroviny1)-L-cysteine (DCVC)-induced lipid peroxidation and toxicity. Slices exposed to DCVC showed a dose-and time-dependent increase in lipid peroxidation (