S-(trans-l,2-Dichlorovinyl)-~-cysteine (DCVC) exposure causes acute renal tubular cytotoxicity. To further characterize the effects of DCVC, a chronic study was undertaken. Male Swiss-Webster mice received DCVC dissolved in their drinking water at 0.01, 0.05 and 0.1 mg ml-'. At 4, 8, 21 and 37 weeks
โฆ LIBER โฆ
Regulation of a S(trans-1,2-dichlorovinyl)-L-cysteine-induced renal tubular toxicity by glutathione
โ Scribed by C. D. Hassall; K. Brendel; A. J. Gandolfi
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 534 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0260-437X
No coin nor oath required. For personal study only.
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Precision-cut, rabbit renal slices were used to examine the effects of three novel antioxidants (U-74006, U-74500, and U-78517) on 5-(1,2-dichloroviny1)-L-cysteine (DCVC)-induced lipid peroxidation and toxicity. Slices exposed to DCVC showed a dose-and time-dependent increase in lipid peroxidation (