Chronic toxicity of S-(trans-1,2-dichlorovinyl)-L-cysteine in mice

✍ Scribed by Deborah R. Jaffe; A. Jay Gandolfi; Raymond B. Nagle

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 694 KB
• Volume: 4
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550040607

✦ Synopsis

S-(trans-l,2-Dichlorovinyl)-~-cysteine (DCVC) exposure causes acute renal tubular cytotoxicity. To further characterize the effects of DCVC, a chronic study was undertaken. Male Swiss-Webster mice received DCVC dissolved in their drinking water at 0.01, 0.05 and 0.1 mg ml-'. At 4, 8, 21 and 37 weeks, animals were terminated. Bladders, spleens, livers, kidneys and eyes were removed for histopathological examination. At 0.05 and 0.1 mg ml-' DCVC, growth retardation was evident by 21 weeks. By 26 weeks, all animals in the 0.1 mg mi-' group had developed cortical cataracts. Cytomegaly, nuclear hyperchromatism and multiple nucleoli were noted in the cells of the pars recta region of the kidney by 4 weeks and correlated to time and dose. At later time points, renal tubular atrophy and early interstitial fibrosis were evident. The epithelial cytological cellular abnormalities appear to be dose-related. Minor pathological changes were noted in the spleen, while there was no effect on the liver or bladder. Chronic ingestion of DCVC results in severe kidney injury.