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In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging

✍ Scribed by Hiromichi Akizawa; Songji Zhao; Masayuki Takahashi; Ken-ichi Nishijima; Yuji Kuge; Nagara Tamaki; Koh-ichi Seki; Kazue Ohkura

Book ID: 116799413
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 333 KB
Volume: 37
Category: Article
ISSN: 0969-8051
DOI: 10.1016/j.nucmedbio.2010.01.005

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## Abstract The expression of thymidine phosphorylase (TP) is strongly associated with angiogenesis in tumors and activation of antitumor agents. We designed a novel 5‐^125^I‐labeled 6‐(2‐iminoimidazolidinyl)methyluracil hydrochloride ([^125^I]5I6IMU‐HCl) to develop an effective radiotracer for __i

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