Synthesis and in vitro Evaluation of 1,2,4-Triazolo[1,5- a ][1,3,5]triazine Derivatives as Thymidine Phosphorylase Inhibitors
✍ Scribed by Bera, Hriday; Dolzhenko, Anton V.; Sun, Lingyi; Dutta Gupta, Sayan; Chui, Wai-Keung
- Book ID
- 120988880
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 914 KB
- Volume
- 82
- Category
- Article
- ISSN
- 1747-0277
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## Abstract **Dedicated to Professor András Messmer on the occasion of his 80^th^ birthday** The reaction of differently substituted 5‐amino‐1,2,4‐triazoles (**5**) with isothiourea derivatives (**3**) to yield isomeric 5,7‐diamino‐1,2,4‐triazolo[1,5‐__a__][1,3,5]triazines (**6** and **7**), previ
## Abstract magnified image __E__‐3‐(__N,N__‐Dimethylamino)‐1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)prop‐2‐en‐1‐one (**2**) was synthesized by the reaction of 1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)ethanone (**1**) with dimethylformamide‐dimethylacetal. The reaction of **2** with