Development of M1 subtype selective musc
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R.D. Schwarz; M.J. Callahan; R.E. Davis; J.C. Jaen; H. Tecle
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Article
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1997
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John Wiley and Sons
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English
β 131 KB
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Clinical trials in Alzheimer's disease (AD) with first generation muscarinic agonists (e.g., arecoline, oxotremorine, pilocarpine) produced inconsistent results due to poor pharmacokinetic properties and a lack of separation between central and peripheral activities observed with these compounds. Se