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In Vitro and in Vivo Evaluation of Phenylbutenoid Dimers as Inhibitors of P-Glycoprotein

✍ Scribed by Chae, Song Wha; Han, Ah-Reum; Park, Jung Hyun; Rhie, Jeong Yeon; Lim, Hee-Jong; Seo, Eun-Kyoung; Lee, Hwa Jeong

Book ID
123606143
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
634 KB
Volume
76
Category
Article
ISSN
0163-3864

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## Abstract Overexpression of the multidrug resistance proteins P‐glycoprotein (Pgp) and breast cancer resistance protein (BCRP) results in treatment failure of many malignancies including ovarian cancer. Dual inhibition of Pgp and BCRP may restore the sensitivity of resistant cells to anticancer d