Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor
✍ Scribed by Javed Iqbal; Juliane Hombach; Barbara Matuszczak; Andreas Bernkop-Schnürch
- Book ID
- 113693381
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 650 KB
- Volume
- 147
- Category
- Article
- ISSN
- 0168-3659
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## Abstract ## Objective To evaluate the effect of duloxetine (DLX) on the P‐glycoprotein (P‐gp) function __in vitro__ and __in vivo__. ## Method __In vitro__ experiment was conducted using the Caco‐2 cell, a human colon cancer cell line that naturally expresses the P‐gp and P‐gp function was ev