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(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation

✍ Scribed by G Luurtsema; C.F.M Molthoff; A.D Windhorst; J.W Smit; H Keizer; R Boellaard; A.A Lammertsma; E.J.F Franssen


Book ID
117687973
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
137 KB
Volume
30
Category
Article
ISSN
0969-8051

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✍ Gert Luurtsema; Albert D. Windhorst; Martien P.J. Mooijer; Jacobus D.M. Herschei πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 French βš– 118 KB πŸ‘ 1 views

## Abstract Racemic (Β±) verapamil is a well characterized substrate for P‐glycoprotein (P‐gp). However, the __in vivo__ pharmacokinetics and pharmacodynamics of both enantiomers are reported to be different. In the preparation of evaluation studies of both enantiomers in animals and humans, the pur