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In vitro and in vivo biological activities of a novel nonpolyglutamable anti-folate, MX-68

✍ Scribed by Masahiko Mihara; Kazumi Urakawa; Nobuhiro Takagi; Yoichiro Moriya; Yasuhisa Takeda


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
437 KB
Volume
35
Category
Article
ISSN
0162-3109

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A derivative of staurosporine (CGP 41 25
✍ Thomas Meyer; Urs Regenass; Doriano Fabbro; Enrica Alteri; Johannes RΓΆusel; Marc πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 632 KB

Analogues of staurosporine were synthesized and their ability to inhibit protein kinases was examined. Staurosporine is a potent but non-selective inhibitor of in vitro protein kinase C (PKC) activity (K5, 6.0 nn). The derivative CGP 41 25 I had reduced PKC activity with an IC,, of 50 nn but showed