The aim of this study was to estimate colon-specific drug delivery of a novel capsule (CS capsule). Theophylline was used as model drug and little was released from the CS capsules in the release medium mimicking physiological environment of stomach to small intestine. However, 66.7 +/- 8.8% theophy
✦ LIBER ✦
CL 284,846, a novel sedative-hypnotic: Evaluation of its metabolites for pharmacological activity in vitro and in vivo
✍ Scribed by Kimberly E. Vanover; Richard M. Mangano; James E. Barrett
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 541 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0272-4391
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## Abstract ## Background Targeted splice modulation of pre‐mRNA transcripts by antisense oligonucleotides (AOs) can correct the function of aberrant disease‐related genes. Duchenne muscular dystrophy (DMD) arises as a result of mutations that interrupt the open‐reading frame in the DMD gene encod