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In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor β on the activation and proliferation of rheumatoid arthritis synovial cells

✍ Scribed by Taku Nagai; Masashi Tanaka; Yasuhiro Tsuneyoshi; Kakushi Matsushita; Nobuhiko Sunahara; Takemasa Matsuda; Hiroki Yoshida; Setsuro Komiya; Masanori Onda; Takami Matsuyama

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 532 KB
Volume: 54
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.22082

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## Abstract ## Objective To determine the expression of folate receptor β (FRβ) in synovial biopsy tissues and peripheral blood lymphocytes from rheumatoid arthritis (RA) patients and to identify novel folate antagonists that are more selective in the targeting and internalization of FRβ than meth