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In vitro and in vivo antitumour activity of a chimeric anti-CD19 antibody

✍ Scribed by Geoffrey A. Pietersz; Li Wenjun; Vivien R. Sutton; Jane Burgess; Ian F. C. McKenzie; Heddy Zola; Joseph A. Trapani

Book ID
105309606
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
831 KB
Volume
41
Category
Article
ISSN
0340-7004

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Chimeric, divalent and tetravalent anti-
Chimeric, divalent and tetravalent anti-CD19 monoclonal antibodies with potent in vitro and in vivo antitumor activity against human B-cell lymphoma and pre-B acute lymphoblastic leukemia cell lines
✍ Xiao-Yun Liu; Laurentiu M. Pop; Lydia Tsai; Iliodora V. Pop; Ellen S. Vitetta πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 295 KB

## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel