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Comparative in vitro study of the immunomodulatory activity of humanized and chimeric anti-CD25 monoclonal antibodies

✍ Scribed by B. KIRCHER; K. LÄTZER; G. GASTL; D. NACHBAUR

Book ID: 110090355
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 81 KB
Volume: 134
Category: Article
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2003.02324.x

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## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel