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In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor

✍ Scribed by Mary B. Mcguire-Goldring; Judith E. Meats; David D. Wood; Earl J. Ihrie; Nicolette M. Ebsworth; R. Graham G. Russell


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
820 KB
Volume
27
Category
Article
ISSN
0004-3591

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## Abstract Interleukin‐1 induces release of NO and PGE~2~ and production of matrix degrading enzymes in chondrocytes. In osteoarthritis (OA), IL‐1 continually, or episodically, acts on chondrocytes in a paracrine and autocrine manner. Human chondrocytes in chondron pellet culture were treated chro