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Interleukin-1β up-regulation of Smad7 via NF-κB activation in human chondrocytes

✍ Scribed by C. Baugé; J. Attia; S. Leclercq; J.-P. Pujol; P. Galéra; K. Boumédiene


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
415 KB
Volume
58
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Protein kinase Cζ (PKCζ), an atypical PKC, has been found to be transcriptionally up‐regulated in human osteoarthritic (OA) articular cartilage. This study was undertaken to examine the role of PKCζ in interleukin‐1β (IL‐1β)–induced NF‐κB signaling in human OA chondrocytes