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IN SITU DETECTION OF THE EPSTEIN-BARR VIRUS-ENCODED NUCLEAR ANTIGEN 1 IN ORAL HAIRY LEUKOPLAKIA AND VIRUS-ASSOCIATED CARCINOMAS

✍ Scribed by MURRAY, P. G.; NIEDOBITEK, G.; KREMMER, E.; GRÄSSER, F.; REYNOLDS, G. M.; CRUCHLEY, A.; WILLIAMS, D. M.; MÜLLER-LANTZSCH, N.; YOUNG, L. S.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
519 KB
Volume
178
Category
Article
ISSN
0022-3417

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✦ Synopsis

A new monoclonal antibody bas been used to examine immunohistochemically the expression of the Epstein-Barr virus (EBV)encoded nuclear antigen (EBNA) 1 in virus-associated epithelial lesions. EBNAl was detected in the tumour cell nuclei of 10113 undifferentiated nasopharyngeal carcinomas and of 10110 EBV-associated gastric carcinomas. EBNAl was also detected in 13 of 16 oral hairy leukoplakia (HL) samples, where its expression was confined to nuclei in the upper epithelial cell layers whilst basal epithelial cells were negative. This observation is in agreement with previous studies demonstrating the absence of latent EBV infection in the basal cell compartment of HL and suggests an essential role for EBNA1, not only in latent EBV infection but also in virus replication.

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