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In silico Prediction of Total Human Plasma Clearance

✍ Scribed by Berellini, Giuliano; Waters, Nigel J.; Lombardo, Franco


Book ID
111965735
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
417 KB
Volume
52
Category
Article
ISSN
0095-2338

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## Abstract Drug binding to Human Serum Albumin (HSA) is an area of intense research. The pharmacokinetics and pharmacodynamics of drugs are strongly affected by their binding to this protein. In this article, the field is reviewed, as well as our models to predict drug‐binding affinities to HSA fr