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In Silico Prediction of Pharmacokinetics Properties

✍ Scribed by Mitsuru Hashida


Book ID
101985259
Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract Improving the ADME profile of drug candidates is a critical step in lead optimization, and because p__K__~a~ affects most ADME properties such as lipophilicity, solubility, and metabolism, it is extremely advantageous to predict p__K__~a~ in order to guide the design of new compounds. H