✦ LIBER ✦

In search of γ-secretase

✍ Scribed by Hardy, John; Israël, Alain

Book ID: 109614341
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 159 KB
Volume: 398
Category: Article
ISSN: 0028-0836
DOI: 10.1038/18979

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## Abstract γ‐Secretase catalyzes intramembrane proteolysis of various type I membrane proteins, including the amyloid‐β precursor protein and the Notch receptor. Despite its importance in the pathogenesis of Alzheimer's disease and to normal development, this protease has eluded identification unt